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doi: 10.1007/s00467-006-0408-8

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This imbalance impairs vasodilation, promotes vasoconstriction, and increases vascular permeability, creating a conducive environment for the infiltration of lipoproteins and immune cells into the arterial wall

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They can react with certain medications and be harmful to people who have kidney disease or seizure disorders

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*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles

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