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doi: 10.1007/s00467-006-0408-8

This imbalance impairs vasodilation, promotes vasoconstriction, and increases vascular permeability, creating a conducive environment for the infiltration of lipoproteins and immune cells into the arterial wall

They can react with certain medications and be harmful to people who have kidney disease or seizure disorders

*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles
