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We show that the inflammatory response elicited by elevated intracellular lipids in skeletal muscle is repressed in Cpt1b m/ mice, strongly supporting the hypothesis that mitochondrial processing of fatty acids is essential for the lipid-induction of inflammation in muscle

Cellular senescence is a state in which cells permanently exit the cell cycle but resist normal apoptotic signaling

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Substitution of other immunosuppressants, for example, methotrexate, also fails to improve symptomatic SFN