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HUVEC and HDMEC were maintained in Endothelial Cell Basal Medium (PromoCell) supplemented with 2% FCS, 0.4% endothelial cell growth supplement, 0.1 ng ml 1 recombinant human EGF (rh EGF), 1 ng ml 1 recombinant human basic fibroblast growth factor, 90 g ml 1 heparin and 1 g ml 1 hydrocortisone

Its the only long-acting amylin analog in late-stage trials, which means it doesnt compete on the same biological turf as GLP-1 drugs

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Additionally, PHMG negatively impacts liver function, heart activity (inducing procoagulant platelet activation), kidneys (causing mild hydropic changes in proximal tubules), and hematopoietic function, leading to changes in erythrocyte counts, hematocrit, and hemoglobin levels