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Modern life pulls hard on that supply: Lawn and garden chemicals (herbicides, pesticides, fertilizers) BPAs and microplastics from chew toys, plastic bowls, and water containers Synthetic preservatives and additives in commercial pet food Diets heavy in processed kibble or high-glycemic carbohydrates Tap water contaminants (chlorine, fluoride, heavy metals) Vaccines and routine veterinary biologics Long-term medications Monthly flea-and-tick preventatives and dewormers When daily toxin load outpaces what your dog's body can produce, glutathione stores run lean

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thus, their main limitation as therapeutics candidates is the short half-life in vivo

Standardized extracts concentrate the active compounds, allowing lower absolute doses with potentially higher potency per milligram