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doi: 10.1146/annurev.bi.52.070183.003431

Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1beta and nerve growth factor in cultured hippocampal neuronal cells

A magnetic stirrer with water bath, liposome extruder, and nanoparticle size analyzer were also used for characterization and analysis

Intriguingly, a significant increase in total and selenium-dependent GPx ratios was observed ( P = 0.0099 and P = 0.0096, respectively) (Figures 6D and E), indicating an adaptive upregulation to mitigate oxidative damage, while the non-selenium-dependent GPx ratio remained stable (Figure 6F)