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However, under excessive or repetitive strain, calcium overload through TRPV4 and Piezo1 triggers activation of NADPH oxidase (NOX) enzymes and mitochondrial ROS production, leading to oxidative damage, inflammatory gene expression, and cell apoptosis (Swain and Liddle, 2021)

Abbreviations ATC: anaplastic thyroid carcinoma AP: apurinic/apyrimidinic or abasic APE1: apurinic/apyrimidinic endonuclease 1 BER: base excision repair GSH: glutathione TME: tumor micro-environment AP probe-net: AP sites capture reagent WB: western blotting RIT: radioiodine therapy DNS: 2,4-dinitrobenzene sulfonamides MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide RMPI 1640: Roswell park memorial institute 1640 FBS: fetal bovine serum DMSO: dimethyl sulfoxide TBST: tris-buffered saline Tween GSS: glutathione enzyme DSBs: double-strand breaks NSCLC: non-small cell lung cancer References Lorimer C, Cheng L, Chandler R, Garcez K, Gill V, Graham K, et al

A recent work [50] defined the primary role of astrocytes in guiding iron transfer from blood to brain tissue