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Approximately 100 dicot species have been identified as Se hyperaccumulators across different families ( Selenium is beneficial to plants in trace quantities, and Se biofortification of crops has gained particular attention in recent years

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These include capsaicin (the active pungent component in chillies), consumption of pungent and spicy foods, alcohol, and pan (betel leaf often combined with tobacco powder and slaked lime)

Finally, the Cyclin D1-CDK4 complex directly phosphorylates speckle-type POZ protein (SPOP), and CDK4/6 inhibitors can enhance the immune escape of tumors by decreasing the ubiquitination of SPOP and reducing the degradation of PD-L1 [56, 57]