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This highlights seleniums broader implications in antioxidant defense, where balanced intake can prevent deficiencies while avoiding toxicity from excess

The rationale for our hypothesis is that the electrophilicity of EA represented by the ,-unsaturated ketone moiety facilitates an irreversible chemical reaction with the highly nucleophilic Cys314 residue in the catalytic triad of FXIIIa, which is the only transglutaminase among all clotting factors, resulting in its inhibition [16, 17]

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