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Additionally, preclinical animal studies have indicated that kratom extract mitigates withdrawal symptoms in morphine-dependent rats and produces analgesic effects comparable to conventional opioids, highlighting the role of serotonergic pathways in kratoms mechanism of action [44, 45]

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Elevated plasma lipid levels lead to increased FA oxidation, and the products of lipid breakdown suppress glucose metabolism, mainly through inhibition of glycolytic enzymes

The genotoxicity of nitrobenzene has been tested in an array of non-mammalian and mammalian test systems in vitro and in vivo
