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Oxidative stress is also closely linked to mitochondrial dysfunction and despite findings are not consistent, it seems that deleted mitochondrial DNA is a manifestation in postmortem brains of patients with BD, which can be equally related to calcium dysregulation [43]
For instance, mice deficient in both GPX1 and GPX2 genes, spontaneously developed ileocolitis at a young age
Jung EJ, Chung KH, Kim CW
