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Many solid tumors show little to no response to ICIs or develop acquired resistance, largely due to the immunosuppressive state of the tumor microenvironment, often referred to as cold tumors [356]

Regarding CAT mRNA expression, an increase in mRNA levels was described in adults with simple steatosis (Aljomah et al

To analyze which cellular processes are affected by expression of SnCE1 and to confirm the subcellular localization of SnCE1 in human cells we next performed microscopy of HeLa cells transiently expressing full length SnCE1, i.e., SnCE1 fl , as well as truncated SnCE1 74-310 , i.e., SnCE1 trunc (Figs

To advance translational applications, future research should focus on: (1) Elucidating interactions between engineered bacteria and the gut microbiota to identify inflammation-related regulatory targets