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Laboratory testing, such as a complete blood count (CBC) and metabolic panel, is done periodically to make sure the treatment is safe and effective, and changes in symptoms, including mobility, functional improvement, and pain levels, are used to track progress

Only a low percentage of adalimumab-treated patients versus placebo had reported pain related to injection in adalimumab clinical trials [45,46,47], and only one reported dropout specifically related to injection-site pain [48] was found in our literature search

This is the catch-22 we discussed earlier in the article

Second, small joint injections (fingers, toes, MCP joints, and IP joints)