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As antimicrobial resistance spreads, the risks associated with common infections, surgical procedures and treatments such as chemotherapy and organ transplants increase dramatically [6]
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This conversion is crucial in reducing the harmful effects of quinolinic acid, a metabolite that worsens neuroinflammation and can lead to neuronal damage [189,190,191]
178 Additionally, the Akt pathway can affect the mitochondrial apoptosis pathway by regulating the activity of apoptosis-related protein kinases such as Bax, Bcl-2, and Bad through phosphorylation, thereby controlling cellular apoptosis
