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Excessive and long-term use can lead to increased blood pressure, fatigue, severe depression, etc

10.1016/j.theriogenology.2019.01.016 45

Two damage detection subpathways exist: global genomic NER (GG-NER) removes DNA damage anywhere in the genome, and transcription-coupled NER (TC-NER) specifically repairs transcription-blocking lesions in actively transcribed DNA
