glutathione with lycopene side effects minimizes skin toxicity and oxidative stress in patients treated panitumumab-containing therapy for metastatic colorectal cancer Lycopene: Benefits, Forms, Dosing, and

10.26402/jpp.2018.3.11 5 Belosic HalleZ.VlainicJ.DrmicD.StrinicD.LueticK.SucicM.et al (2017)

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It is particularly noted that GSH regulated redox state may control cell function through gene induction, transcriptional, translational, posttranslational, or receptor-mediated effects, on a variety of factors

However, this concept must be modified, since it is now known that certain conjugation reactions (acyl glucuronidation of nonsteroidal antiinflammatory drugs, O-sulfation of N-hydroxyacetylaminofluorene, and N-acetylation of isoniazid) may lead to the formation of reactive species responsible for the hepatotoxicity of the drugs