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Senolytic therapies may eliminate senescent cells but may not fully resolve the long-term inflammatory consequences of their presence, while senomorphic agents may suppress the SASP but leave senescent cells intact, allowing them to persist and potentially cause harm.210 Combining both approaches addresses the complexity of senescence, offering a more holistic therapeutic strategy for aging-related conditions.45 Potential Applications of Combination Therapies The combination of senolytic and senomorphic therapies has broad potential applications in age-related diseases and conditions

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Paired (in group) and unpaired (between groups) Student t -test were used in microCT analysis