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Mechanistic Actions: Free radical scavenging in aqueous humor Collagen synthesis support for corneal and scleral integrity Regeneration of vitamin E from its oxidized forms Protection against advanced glycation end-product formation Clinical Evidence: Epidemiological studies demonstrate inverse correlations between dietary vitamin C intake and cataract risk, with the highest quintile of intake showing 45% reduced risk of posterior subcapsular cataracts compared to the lowest quintile of consumers

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In general, the H2R demonstrates predominantly anti-inflammatory effects: In T-cells, H2R activation can suppress certain T-cell responses and may favor TH2 polarization and production of IL-10 [59]

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