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Free Radic Biol Med 111: 262269, 2017
Activated FoxO upregulates the expression of the muscle-specific E3 ubiquitin ligases Atrogin-1 and MuRF-1, orchestrating the proteasomal degradation of key contractile proteins and driving muscle atrophy (59)
"I told a friend that I was doing the best work of my career," he says, "and he said I had been telling him that for 30 years." "Getting old is just like getting irradiated," says Bruce Ames, whose quest during the twilight of his career is to find ways to combatand possibly reversethe destructive effects of ordinary cellular metabolism
