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Fluorescence density of PAMAM-PEG-Tf/TMZ in TfR+ glioma stem cells (GSCs) was significantly higher than that of matched non-stem cells and active apoptosis of tumor cells could be observed after the uptake of PAMAM-PEG-Tf/TMZ, suggesting that targeting transferrin receptors to deliver TMZ is a potential GSC-mediated treatment method (182)

Pavl J, Kerchev P, ern M, Novk J, Berka M, Jobe TO, Lpez Ramos JM, Saiz-Fernndez I, Rashotte AM, Kopriva S, Brzobohat B (2022) Cytokinin modulates the metabolic network of sulfur and glutathione

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The Th1/Th2 imbalance in ME/CFS drives broader immune dysregulation, including overreaction to pathogens and mismanagement of immune responses against host tissues, potentially contributing to the autoimmune features of ME/CFS