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Conversely, the RabGTPase-activating protein TBC1D4 knockout exacerbates IRI 27
A recent study showed that besides heme and metHb, large amounts of covalently crosslinked Hb multimers (dimers and tetramers) accumulate in the cerebrospinal fluid of preterm infants following IVH (112)

10.1016/j.biopha.2024.116160 153 VermaM.RhodesM.ShintonS.WiestD

Supplementing with collagen helps fill that gap, gradually restoring some of that structure you didn't notice losing until it was gone
