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Contemporaneously, studies of synthetic guanidine analogues discovered a compound referred to as flumamine and suggested that it might act in patients with malaria by lowering blood glucose, thereby reducing the ability of the malarial parasite to survive

[DOI] [PMC free article] [PubMed] 99.Caprariello AV, Rogers JA, Morgan ML, Hoghooghi V, Plemel JR, Koebel A, Tsutsui S, Dunn JF, Kotra LP, Ousman SS, et al

Annu Rev Pharmacol Toxicol 18:5779 Gomez-Sintes R, Bortolozzi A, Artigas F, Lucas JJ (2014) Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice

Sensitive individuals may start lower, but 1 mg remains the standard maintenance floor