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Description
First, angiogenesis is initiated in response to stimulation from hypoxia, inflammation and reactive oxygen species in the tumor microenvironment (TME)

(UKNEQAS issued a B12 treatment Alert instructing doctors to do this - included in some links below)

The peptide selectively accumulates in the inner mitochondrial membrane where it binds to cardiolipin, a specialized phospholipid essential for organizing electron transport chain supercomplexes and maintaining cristae structure [2][7]

doi: 10.1016/S0165-5728(02)00095-4