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Research suggests that high doses can lead to potential side effects, including: Gastrointestinal Issues: High doses may cause nausea, diarrhea, and abdominal discomfort

Our observation that intracellular NA concentrations did not increase following NNMT inhibition extends previous studies that showed NA concentrations were largely unaffected following NNMT knockdown with either adenovirus[39] or anti-sense oligonucleotides (ASOs).[12] It is possible that significant accumulation of NA in adipocytes (and other tissues) is prevented by rapid conversion of NA to NMN and subsequent NAD + synthesis or transport to the extracellular environment.[27] Importantly, NNMT inhibition potentiated the absolute intracellular concentrations of NAD + and SAM, without altering the levels of NA and SAH in the adipocytes

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NAMPT-overexpressing cells, either in the mass culture or tumorspheres, were more sensitive to FK866 than were parental cells or cells with reduced levels of NAMPT
