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The breadth of documented activity reflects what the original investigators have described as systems-level pharmacology: rather than acting through a single high-affinity receptor, BPC-157 appears to modulate multiple intersecting cellular pathways including nitric oxide signalling, growth-factor receptor expression, dopamine and serotonin metabolism, and angiogenic vessel formation

2.4 Neurotrophin 2.4.1 Nerve growth factor While keratinocytes are the primary source of skin-derived NGF, dermal inflammatory cells such as mast cells, eosinophils, and lymphocytes abundantly secrete NGF in lesional PN skin (95, 96)

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