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[48] Severe hepatic impairment may represent a relative contraindication to ondansetron use, as the drug undergoes extensive hepatic metabolism

Neuefeind T, Huber R, Dasenbrock H, Prade L, Bieseler B: Crystal structure of herbicide-detoxifying maize glutathione S -transferase-I in complex with lactoylglutathione: evidence for an induced-fit mechanism

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These findings present not only a novel understanding of the pathogenesis of IBD, but may also aid in the development of therapeutic approaches for IBD and other intestinal diseases
