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Description
Research in Drosophila melanogaster demonstrated geroprotective effects at concentrations 16,000-80,000,000 times lower than those required for melatonin, suggesting Epithalon functions through highly efficient regulatory mechanisms rather than stoichiometric antioxidant consumption

The stability of this barrier depends critically on the integrity of tight junctions

Liver-specific PHGDH knockout (KO) mice fed a chow diet show higher adiposity and reduced glucose tolerance (25)

(PubMed) Hyson HC, Kieburtz K, Shoulson I, et al
