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I/R injury is also a major concern in cerebral ischemia (stroke) and renal injury (kidney), highlighting the broad impact of ischemia-reperfusion across multiple organs

470 In animal models of Apelin-13-caused cardiomyocyte hypertrophy and heart failure, NCOA4-activated ferritinophagy leads to the upregulation of SFXN1 expression, causing mitochondrial iron overload and mitochondrial ROS overproduction, increased lipid peroxidation, and ultimately, ferroptosis

6d and Supplementary Fig
A Systematic Review