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82 In addition, LNPs can be loaded with both lipophilic and water-soluble therapeutic drugs due to their hydrophilic and phobic properties, where the hydrophilic drugs can be loaded inside, and the lipophilic drugs can be encapsulated in phospholipid bilayers or adsorbed on the surface of liposomes, 83 moreover, such LNPs loaded with therapeutic drugs can increase drug concentrations in tumor cells, reduce therapeutic dose and toxicity, and treatment resistance compared to free drugs
It is a layered cascade involving mucosal barrier degradation, cytokine overproduction, dysregulated immune signalling, and mitochondrial dysfunction
in a single-center prospective study, 389 children with epilepsy treated with KD experienced hyperlipidemia at a rate of 50.8%
[DOI] [PubMed] [Google Scholar] 230.Yamada Y, Obayashi M, Ishikawa T, Kiso Y, Ono Y, Yamashita K
