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Description
Weight loss begins but may be modest, averaging 2-4 pounds depending on starting weight and dose

To determine whether elevated CCK expression within the mPFC underlies the increased vulnerability to SDS-induced anxiety in adult KI mice, we used a viral-mediated short hairpin RNA (shRNA) strategy driven by the CaMKII promoter to selectively attenuate Cck expression in mPFC excitatory neurons

Such genetic alterations were all reverted by low doses if IGF-1 replacement therapy for only 10 days

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