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Furthermore, research using models where anthraquinones like emodin (EMO) themselves induce injury has revealed how protective flavonoids such as isoliquiritigenin work by upregulating cellular detoxification and antioxidant defenses via the Nrf2/Keap1 pathway, showcasing the models utility in studying herb-herb interactions or intrinsic toxicity mitigation (Ni et al., 2022)

2009;297:C1249C1262

In the control group (Figure 3A, 3B), a few GFAP-positive immunoreactive astrocytes were detected among the pyramidal cells in CA3 and dentate gyrus, with many dispersed among the molecular layers

In 2003, erastin was identified as a selective inducer of non-apoptotic cell death in cancer cells dependent on ST- and RASG12V, 39 along with the involvement of the RAS/BRAF/MEK/MAPK pathway and voltage-dependent anion channel (VDAC) that mediate oxidative stress and mitochondrial dysfunction, respectively