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In the CKD milieu, various uremic toxins, oxidative stress, and inflammatory factors can accelerate the eryptosis process, leading to a significant reduction in red blood cell lifespanfrom the normal 120 days toonly 6090 days in CKD patients

Three crucial factors contributing to ferroptosis include the availability of intracellular iron, membrane lipid peroxidation, and the loss of antioxidant defenses

1.72-5 [36] was used to explore the co-expression pattern of metabolites and ASVs in response to the prenatal nutrition effects

Particularly in liver cirrhosis associated with thalassemia major, which concomitantly can impair pituitary GH secretion, there is no secondary upregulation of local IGF-I and linear growth failure is common (95)