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This perception was particularly reinforced by the fact that six Ginkgo trees growing between one and one and a half kilometres from the 1945 atomic explosion at Hiroshima, Japan, were amongst the few living organisms to survive the blast

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Early studies from the late 1990s reported that supplementation at 12 grams per day improved mood and reduced fatigue in patients with major depressive disorder, as evidenced by reductions in Hamilton Depression Rating Scale scores by about 2030% over 48 weeks [5]

These biotherapeutic strategies for OA aim to modulate or inhibit the effects of major cytokines, similar to the approach for RA treatment (206)