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For example, SOD1 is metalated by the copper chaperone for superoxide dismutase (CCS) (Culotta et al., 1997

Specifically, Kang et al (157) showed that lanosterol binds to the hydrophobic dimerization interface to disrupt the aggregation of human D-crystallin

However, the contribution of these oxalate transporters to oxalate homeostasis and risk for hyperoxaluria in humans needs to be further defined [49]

Clinicians should not present MOTS-c benefits to patients as proven, and should be candid about the wide gap between preliminary laboratory findings and clinical proof
