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This process leads to urine retention in the kidney with simultaneous increase in intrarenal pressure, destruction of the renal parenchyma, and kidney failure resulting in hydronephrosis

FabianFKacprowskiTRhlemannMPietznerMBangCFrankeAet al

CellTox Green can be combined with other methods in multiplex assays to determine mechanism of toxicity, and is easily scalable from 96- to 1536-well plate formats

Cluster determinant 36 (CD36), an essential glycoprotein responsible for fatty acid uptake, exacerbates oxidative stress and induces the apoptosis of -cells under hyperglycemic conditions through pathways involving ceramide, thioredoxin-interacting protein (TXNIP), and Rac1-nicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated redoxosome formation