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Side Effects: Cyanocobalamin is generally well-tolerated, but some patients might experience side effects, including

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Thus, aldose reductase activity consumes NADPH (Figure 4), a critical cofactor necessary for the regeneration of the primary lens antioxidant, glutathione (GSH), from its oxidized form (GSSG)

The dose of BAY11-7082 was chosen based on our preliminary results of dose response, which showed that 10 M BAY11-7082 significantly increased the number of surviving SGNs after cisplatin damage in vitro (Supplementary Figure 2)
