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We considered transcripts with a q-value 0.15 to be rhythmic, based on the threshold used by Hughes et al ., and on the q-values of core clock transcripts in this dataset ( Clk-RA , q-value = 0.1475

Normal and expected reactions include a brief stinging or burning sensation during or immediately after injection, mild redness or warmth at the injection site lasting a few minutes, and small temporary lumps that resolve within 30 to 60 minutes as the solution disperses through subcutaneous tissue

Multi-dose formulations such as Hospira bacteriostatic water injection (which has 0.9 percent benzyl alcohol to aid in longer shelf life)

We also examined gene expression changes induced by C1-27 in HCT116 cells after 4 and 24 h treatment to observe the early and late response to GSTO1 inhibition, respectively (Supplementary Tables 1417 and 2023)