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genes and enzymes that make glutathione transferases: substrates, inihibitors pro-drugs in cancer and neurodegenerative diseases Glutathione Metabolism - an overview
Description
The third pathway is proline utilisation which occurs in mitochondria where proline is oxidised to pyrroline-5-carboxylate by mitochondrial proline dehydrogenase ( PUT1 ) which, in turn, is further oxidised to glutamate by 1-pyrroline-5-caboxylate dehydrogenase ( PUT2 ) 19

Li GY, Song ZW, Ru Y, et al

As understanding of tumor heterogeneity deepens, selecting and prioritizing combination strategies tailored to specific TME profiles such as tumors with high MDSC infiltration or varying levels of PD-L1 expression will be critical for advancing cancer immunotherapy

[DOI] [PubMed] [Google Scholar] 308
