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There is mounting evidence that elevated plasma homocysteine (and therefore decreased serum methionine) contributes to congenital neural tube defects

HDIVC typically involves doses ranging from 15-100g administered over 1-3 hours, depending on the patient's weight, kidney function, and treatment goals

Asada K (2006) Production and scavenging of reactive oxygen species in chloroplasts and their functions

While it is known that ROS are generated as a by-product of cancer cell growth (65), a more comprehensive understanding of the redox landscape could potentially help guide rational patient selection for drugs that exploit this sensitivity (18, 19)