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3 Likes GENERAPHARM August 5, 2022, 9:00am 13 I agree totally about different mechanisms for nitroso-amides however as long as ICH M7 CoC uses the term nitroso the regulators will continue to pursue the issue and I dont see much chance of getting a change in the ICH guidance
10.1007/s12265-015-9619-3 20 EguchiS.HirataY.MarumoF

Adaptability calculation and search for potential anti-aging strategies As described in the main text, the adaptability calculation was a modified sensitivity analysis with perturbation of one parameter at a time by 20% of its initial value and subsequent calculation of the difference between the resting and stimulated states sensitivities, normalized by the resting state sensitivities (see Equation 1 above)
