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In a study of 23 postmenopausal women with a history of hysterectomy, after 12 months of daily oral conjugated estrogen (0.625 mg) or daily 17-estradiol transdermal patches (50 g), carbohydrate oxidation increased in the oral group and decreased in the transdermal group, whereas fatty acid oxidation decreased in the oral group and increased in the transdermal group (132)