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5 Many of the clinical benefits of NAC are based on its ability to correct or prevent GSH depletion

Yet the cognitive enhancement effects triggered during exposure persist for weeks through sustained upregulation of hepatocyte growth factor (HGF) and its receptor c-Met in hippocampal tissue

For example, mu opioid receptors are important mediators of the rewarding effects of opiates such as heroin, and also undergo adaptations in function in response to drug exposure (Atwood et al., 2014a)

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