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doi: 10.1002/ptr.6212
The authors prove that the manganese (Mn 2+ ) treatment-induced tumor cell death is irrelevant to the apoptosis, necroptosis, pyroptosis or autophagy, but only to ferroptosis, in which type I interferons (IFNs) were the main mediators of downregulated DHODH expression and subsequent mitochondrial ROS accumulation
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