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The most appropriate moments to consider it are when symptoms are already present (cramps, headache, dizziness, dark urine) or when fluid loss has been extreme enough that drinking alone wont catch up before symptoms get worse
The significance of metabolic reprogramming is to promote the growth and proliferation of tumor cells by generating energy, synthesizing necessary precursors and maintaining oxidative balance, especially under hypoxic and hypo-nutrient conditions (17)
doi: 10.1331/JAPhA.2009.09078
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