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Animals were housed in cages kept at standardized conditions (22 5 C, 55 5% humidity, and 12 h light/dark cycle)

Regular moderate exercise (150 minutes per week of walking, swimming, or cycling) combined with two sessions of strength training preserves bone density and hormonal balance during weight lossavoiding excessive cardio-only regimens that can worsen menstrual disruption in susceptible individuals

J Appl Physiol 113:10513

Our findings raise the notion that reductions in key antioxidant mechanisms may be the biological risk factor for the development of konzo, particularly those mediated through pathways involving the glutathione peroxidase family