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10.1128/JB.188.4.1364-1372.2006 53

Subcutaneous angiolipomas are assumed to be congenital in origin where pubertal hormones may induce differentiation of adult adipose-derived stromal adipogenic precursors that reside in adipofascia

although several candidate genes such as MAP4K4, E2F6 , and UBE2N have demonstrated preclinical promise, their translation into clinical settings remains at an early stage, highlighting the need for further in vivo validation and tumor-specific delivery strategies

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