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Loss of cytoplasmic bulk and reduction in size might be expected in situations of permanent loss of synaptic connections (e.g., trans-synaptic degeneration), as when central axons undergo Wallerian degeneration but fail to regenerate
Cerebral ischemia and neuronal damage resulting from Alzheimers disease (AD) and multi-infarct dementia (MID) may lead to the progression of symptoms of cognitive deficits [36]
