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Indeed, in cancer cells, the activation of the PKM gene and the synthesis of the PKM2 isoform of pyruvate kinase promotes glucose diversion into pathways conducive for biomass production
It wastes time
It is also important in drug metabolism, as most phase I enzymes including cytochrome P450 oxidases and some phase II enzymes localize to the ER 54
In: Kolb H, Fernandez E, Nelson R (eds) Webvision: the organization of the retina and visual system, Salt Lake City (UT) Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
