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Reactive oxygen species (ROS) are generated through interaction of the excited state chromophore with a variety of substrates, which go on to oxidatively damage biomolecules (37)

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Direct evidence from multi-omics analyses of airway host-microbe interactions in COPD patients indicated that indole-3-acetic acid (IAA) derived from airway microbiota alleviated neutrophil inflammation, cell apoptosis, emphysema, and lung function decline through IL-22-mediated macrophage-epithelial cell interactions

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