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The antioxidant system involved in the defense against ferroptosis is mainly controlled by the transcription factor nuclear factor erythroid-2-related factor (NRF2), which is known to induce the expression of antioxidant enzymes and lipid detoxification enzymes [46]

This study also demonstrated that women who got their folate from dietary sourcessuch as oranges, leafy greens, and beansdid not derive the same benefit as those taking folic acid supplements

There have been several other molecular dynamics studies of oxidized lipid bilayers that can also shed light on the biophysical mechanisms underlying ferroptosis 12,13,14,15,16,17,18,19,20

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