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(2019) A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia

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The action of mitochondrial enzymes in the metabolism of serine and glycine, in addition to those involved in folate metabolism, have been recently shown to be determinants of the response to methotrexate, suggesting that patients whose tumours show upregulation of serine and glycine mitochondrial enzymes are sensitive to folate antagonists targeting thymidylate or purine biosynthesis [51]

For lactate uptake/oxidation inhibition experiments (Fig